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LCZ696 Entresto

Sacubitril|Valsartan

CAS: 936623-90-4

Molecular Formula: C48H58N6O8

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LCZ696 Entresto - Names and Identifiers

Name Sacubitril|Valsartan
Synonyms LCZ696
LZC696
Entresto
LCZ696 Entresto
LCZ696 ENTRESTO TM
Sacubitril mixture with Valsartan
Cocrystal of Sacubitril and Valsartan
[(C24H29N5O3).(C24H29NO5).2.5(H2O).3Na]
4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
CAS 936623-90-4
EINECS 000-000-0

LCZ696 Entresto - Physico-chemical Properties

Molecular FormulaC48H58N6O8
Molar Mass847.03
Solubility 10 mM in DMSO
Storage Condition-20℃
In vivo studyIn double transgenic rats overexpressing human renin and angiotensinogen and Plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) causes a dose-dependent and persistent decrease in mean arterial pressure (MAP) and stimulates a rapid dose-dependent increase in plasma ANP immunoreactivity. LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing myocardial fibrosis and hypertrophy in a rat myocardial infarction (MI) model.
In double transgenic rats overexpressing human renin and angiotensinogen and Plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) causes a dose-dependent and persistent decrease in mean arterial pressure (MAP) and stimulates a rapid dose-dependent increase in plasma ANP immunoreactivity. LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing myocardial fibrosis and hypertrophy in a rat myocardial infarction (MI) model.

LCZ696 Entresto - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.044 ml5.219 ml10.439 ml
5 mM0.209 ml1.044 ml2.088 ml
10 mM0.104 ml0.522 ml1.044 ml
5 mM0.021 ml0.104 ml0.209 ml
Last Update:2024-01-02 23:10:35
LCZ696 Entresto
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Shanghai Macklin Biochemical Co., Ltd
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CAS: 936623-90-4
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SKYRUN INDUSTRIAL CO.,LTD
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Email: sales@chinaskyrun.com
Mobile: +8618958170122
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 936623-90-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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SHANDONG SIHUAN PHARMACEUTICAL CO., LTD
Product Name: Sacubitril/Valsartan Request for quotation
CAS: 936623-90-4
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327 Click to send a QQ messageSend QQ message
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: LCZ696 Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Amole Biotechnology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: LCZ696 Request for quotation
CAS: 936623-90-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: LCZ696 Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Spot supply
Product Name: LCZ696 Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
     tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: LCZ696 Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: LCZ696 Visit Supplier Webpage Request for quotation
CAS: 936623-90-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
SHANDONG SIHUAN PHARMACEUTICAL CO., LTD
Product Name: Sacubitril/Valsartan Request for quotation
CAS: 936623-90-4
Tel: 0531-88990216
Email: fairouz@sdsihuanpharm.com
Mobile: 13335127975
QQ: 824027327 Click to send a QQ messageSend QQ message
View History
LCZ696 Entresto
AKOS BB-9465
卡波普
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